The Oxford English Dictionary's first recorded utterance of the word racism was by a man named Richard Henry Pratt in 1902. Pratt was railing against the evils of racial segregation.

Segregating any class or race of people apart from the rest of the people kills the progress of the segregated people or makes their growth very slow. Association of races and classes is necessary to destroy racism and classism.

Although Pratt might have been the first person to inveigh against racism and its deleterious effects by name, he is much better-remembered for a very different coinage: Kill the Indian...save the man.

"A great general has said that the only good Indian is a dead one," Pratt said. "In a sense, I agree with the sentiment, but only in this: that all the Indian there is in the race should be dead. Kill the Indian in him, and save the man."

We're still living with the after-effects of what Pratt thought and did. His story serves as a useful parable for why discussions of racism remain so deeply contentious even now.

http://www.npr.org/sections/codeswitch/2014/01/05/260006815/the-ugly-fascinating-history-of-the-word-racism